Nghiên cứu sử dụng bột vỏ trứng làm tá dược trong viên nén chứa hoạt chất acetaminophen
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Abstract
Eggshell waste, a valuable raw material, can be used as an alternative excipient ingredient in pharmaceutical tablets. For this, the present study modified the eggshell powder surface and mixed with acetaminophen using the direct compression method. The structural characteristics were clarified through Fourier-transform infrared spectroscopy (FT-IR). The dissolution profiles of various tablet formulations were investigated in simulated physiological environments (phosphate buffer pH 5.8) and from gastric fluid pH 1.2 to intestinal fluid pH 6.8. The results showed that the acetaminophen coated with untreated eggshell powder was rapidly released. In contrast, tablets containing 15% eggshell powder treated with deionized water were sustainably released, similar to commercial products. In conclusion, the eggshell powder can be reused as a replacement excipient to control the release of various active tablet ingredients.
Tóm tắt
Phế phẩm vỏ trứng là nguồn nguyên liệu thô hữu ích và có thể sử dụng như một thành phần tá dược thay thế trong các sản phẩm thuốc dạng viên nén. Trong nghiên cứu này, bột vỏ trứng (BVT) được tiến hành xử lý bề mặt và phối trộn với acetaminophen bằng phương pháp dập trực tiếp. Đặc trưng cấu trúc của sản phẩm được làm rõ qua quang phổ hồng ngoại biến đổi Fourier (FT-IR). Khả năng giải phóng hoạt chất của các công thức viên nén khác nhau được khảo sát trong môi trường mô phỏng sinh lý (đệm phosphate pH 5,8) và môi trường dạ dày (pH 1,2) sang ruột non (pH 6,8). Kết quả cho thấy, acetaminophen giải phóng nhanh trong viên nén chứa BVT chưa qua xử lý trong các điều kiện khảo sát. Mặt khác, viên nén chứa 15% thành phần khối lượng BVT đã qua xử lý với nước khử ion phóng thích hoạt chất kéo dài tương đồng với thuốc thành phẩm. Tóm lại, vỏ trứng có thể được tái sử dụng như một tá dược thay thế, kiểm soát sự giải phóng các hoạt chất khác nhau trong viên nén.
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