Phan Thành Đạt , Lâm Vĩ Nhã , Nguyễn Nguyền Trân , Phùng Thị Hằng Nguyễn Trọng Hồng Phúc *

* Người chịu trách nhiệm về bài viết: Nguyễn Trọng Hồng Phúc (email: nthphuc@ctu.edu.vn)

Abstract

Stomach ulcers are a common gastrointestinal disease and there have been many studies and strategies to prevent this disease. Many studies have been done subclinical and clinical to find preventive drugs, but the animal model of stomach ulcers has not been agreed. This study was performed to evaluate 3 models of acute gastric ulcer in Mus musculus by ethanol (60°, 70° and 80°), acetic acid (10%, 15% and 20%) and aspirin (350 mg/kg, 500 mg/kg and 650 mg/kg) with the evaluation criteria of total acidity, ulcer index by depth, length and area of ​​the ulcer. The results showed that all 3 ulcer agents could cause stomach ulcers, in which 70° ethanol, 10% acetic acid and 500 mg/kg Aspirin were suitable agents to make stomach ulcer mice models.

Keywords: Acetic acid, Aspirin, Ethanol, Stomach ulcer model

Tóm tắt

Viêm loét dạ dày là bệnh đường tiêu hóa phổ biến và đã có nhiều nghiên cứu, phát đồ phòng trị bệnh này. Nhiều nghiên cứu được thực hiện cận lâm sàng và lâm sàng nhằm tìm ra các loại thuốc phòng trị nhưng mô hình động vật bị loét dạ dày vẫn chưa được thống nhất. Nghiên cứu này thực hiện khảo sát 3 mô hình loét dạ dày cấp tính trên chuột nhắt trắng Mus musculus bởi ethanol (60o, 70o và 80o), acetic acid (10%, 15% và 20%) và aspirin (350 mg/kg, 500 mg/kg và 650 mg/kg) với các chỉ tiêu đánh giá về tổng độ acid, chỉ số loét theo độ sâu, chiều dài và diện tích vết loét. Kết quả cho thấy cả 3 tác nhân gây loét đều có thể gây loét cấp dạ dày, trong đó, ethanol 70o, acetic acid 10% và aspirin 500 mg/kg là các tác nhân phù hợp để xây dựng mô hình gây loét dạ dày cấp tính.

Từ khóa: Acetic acid, Aspirin, Ethanol, mô hình loét dạ dày

Article Details

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