Tổng hợp dẫn xuất N-(3-morpholinopropyl)benzimidazole

Lê Đức Anh * , Bùi Thị Bửu Huê , Nguyễn Quốc Châu Thanh , Phùng Văn Bình và Lê Trọng Hiếu

* Tác giả liên hệ (anhm0914001@gstudent.ctu.edu.vn)

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Ngày nhận bài: 09-08-2016
Ngày duyệt đăng: 28-04-2017
Ngày xuất bản: 28-04-2017
Title: Synthesis of N-(3-morpholinopropyl)benzimidazole derivatives
DOI: 10.22144/ctu.jvn.2017.012
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Trích dẫn
Anh, L. Đ., Huê, B. T. B., Thanh, N. Q. C., Bình, P. V., & Hiếu, L. T. (2017). Tổng hợp dẫn xuất N-(3-morpholinopropyl)benzimidazole. Tạp chí Khoa học Đại học Cần Thơ, (49), 84-92. https://doi.org/10.22144/ctu.jvn.2017.012
Số báo
Số. 49 (2017)
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Tự nhiên

Abstract

A one-step synthetic pathway of N-(3-morpholinopropyl)benzimidazole has been developed including in situ reduction/cyclization of N-alkyl-o-nitroanilines and aldehydes using Na2S2O4 as the reducing agent. Based on this method, ten new N-(3-morpholinopropyl)benzimidazole derivatives have been successfully synthesized in moderate to excellent yields (42-91%). The structures of these new compounds were fully confirmed by various spectroscopic methods such as MS, IR, 1H-NMR and 13C-NMR.
Keywords: Benzimidazole, N-alkylbenzimidazole, sodium hydrosulfite

Tóm tắt

Phương pháp một bước đơn giản gồm sự khử/đóng vòng in situ các N-alkyl-o-nitroaniline và các aldehyde tương ứng tạo ra dẫn xuất N-alkylbenzimidazole sử dụng tác nhân oxy hóa là Na2S2O4. Dựa trên phương pháp này, mười dẫn xuất mới N-(3-morpholinopropyl) benzimidazole đã tổng hợp thành công với hiệu suất từ 42-91%. Cấu trúc của các dẫn xuất được xác nhận bằng các phương pháp phổ nghiệm hiện đại như MS, IR, 1H-NMR và 13C-NMR.
Từ khóa: benzimidazole, N-alkylbenzimidazole, sodium hydrosulfite

Article Details

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