Nghiên cứu tiềm năng kháng ung thư của cao chiết nắp ấm hoa đôi (Nepenthes mirabilis)
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Abstract
This study evaluates the potential anti-cancer activity of the Nepenthes mirabilis extract using human cancer cell lines. The results indicated that the extract can inhibit the growth of cervical carcinoma cells (HeLa) with IC50 values of 151.35 and 158.49 µg/mL, representing the selectivity index (SI) values of 1.86 and 1.26 for 24 and 48 hours of treatment, respectively. Additionally, the extract showed inhibitory effects on colorectal adenocarcinoma cells (HT-29) with an IC50 value of 141.25 µg/mL within an SI value of 1.41 for 48 hours of treatment. Furthermore, the total polyphenol and flavonoid content exhibited high values of 538.20 mgGAE/g and 367.08 mgQE/g of dried extract. Our findings enhance the scientific understanding of Vietnamese flora and pave the way for developing potent herbal cancer therapies.
Tóm tắt
Nghiên cứu này được thực hiện nhằm đánh giá tiềm năng kháng ung thư của cao chiết Nắp ấm hoa đôi (Nepenthes mirabilis) trên một số dòng tế bào ung thư thử nghiệm. Kết quả cho thấy, cao chiết có khả năng ức chế sự phát triển của các dòng tế bào ung thư biểu mô cổ tử cung (IC50 = 151,35 và 158,49 µg/mL, chỉ số chọn lọc SI = 1,86 và 1,26, sau 24 và 48 giờ điều trị) và ung thư biểu mô đại trực tràng (IC50 = 141,25 và SI = 1,41 ở 48 giờ điều trị). Ngoài ra, hàm lượng polyphenol và flavonoid toàn phần trong cao chiết Nắp ấm hoa đôi được xác định trong nghiên cứu lần lượt là 538,20 mgGAE/g và 367,08 mgQE/g cao chiết. Những kết quả này không chỉ bổ sung tài liệu khoa học về các loài thực vật ở Việt Nam mà còn mở ra những cơ hội mới trong việc phát triển các liệu pháp điều trị ung thư hiệu quả hơn từ thảo dược.
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