Bào chế hệ vi hạt từ fibroin tơ tằm phối trộn polymer định hướng ứng dụng dẫn truyền thuốc đường uống
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Abstract
Silk fibroin is a biomaterial commonly utilized in numerous medical applications. However, limited information has been reported on fibroin usage in oral drug delivery. Thus, this study was conducted. Fibroin was successfully extracted from silk cocoons with a 20.08% extraction efficiency. The fibroin nanoparticles, functionalized with poly(vinyl alcohol) or Eudragit E100, were effectively formulated by the desolvation method, with nano-sizes and high stability in the simulated gastrointestinal condition. The Fourier-transform infrared (FT-IR) spectroscopy was used to examine the system structure, which revealed the distinctive peaks of all components. Using a scanning electron microscope (SEM), the nanoparticle system was spherical. In conclusion, the research successfully developed novel polymer-functionalized silk fibroin nanoparticles for oral drug delivery.
Tóm tắt
Fibroin tơ tằm là một vật liệu y sinh đã được ứng dụng phổ biến trên thế giới. Tuy nhiên, vẫn còn ít nghiên cứu đề cập đến việc bào chế hệ vi hạt từ fibroin nhằm dẫn truyền thuốc đường uống. Đây là lý do để nghiên cứu này được thực hiện. Fibroin đã được chiết thành công từ kén tơ tằm Việt Nam với hiệu suất chiết 20,08% với các đặc tính lý hóa đặc trưng của phân tử fibroin. Hệ vi hạt fibroin phối trộn poly(vinyl alcohol) và Eudragit E100 được bào chế thành công bằng phương pháp đổi dung môi với kích thước nano và bền vững trong môi trường mô phỏng đường tiêu hóa. Cấu trúc hệ được phân tích bằng quang phổ hồng ngoại (Fourier-transform infrared spectroscopy, FT-IR) cho thấy đầy đủ các mũi đặc trưng của các thành phần trong hệ. Hình dạng hệ vi hạt được quan sát bằng hiển vi điện tử quét (SEM) cho thấy hệ có dạng hình cầu. Tóm lại, nghiên cứu đã bào chế thành công hệ vi hạt từ fibroin tơ tằm phối trộn polymer định hướng dẫn truyền thuốc đường uống.
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