Tổng hợp vật liệu nano Fe3O4@SiO2 chức năng hóa bề mặt với chitosan
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Abstract
This study aimed to synthesize and characterize Fe3O4@SiO2 nanoparticles with a core-shell structure functionalized with chitosan. Fe3O4 nano particles were firstly synthesized by the co-precipitation method and then covered with SiO2 by using a silane compound derived from tetraethyl orthosilicate (TEOs) used as a reagent for phase transition with an advantage of high bioadaptability with silica dioxide shell. The nanoparticles covered with silica dioxide were funtionalized with chitosan, a polymer with bioadaptable characteristics highly applied for biomedical. The result of X-ray analysis of nanoparticles Fe3O4 showed a high crystalline structure and the result of particle morphology using a vibrating sample magnetometer and transmission electron microscope (TEM) analysis presented that the particles were in the shape of octahedral nanoparticles and the particle size including SiO2 shell was about 20 nm. Fourier transform infrared spectroscopy of Fe3O4@SiO2/CTS showed that the apperance of peaks of C–O, N–H, C–H bonding illustrated the presence of chitosan on the surface of Fe3O4@SiO2 after the functionalizing step. The result of a vibrating sample magnetometer determined super-paramegnetic properties of the as-synthesized material and the saturation magnetization value (Ms) of Fe3O4, Fe3O4@SiO2, and Fe3O4@SiO2/CTS was 92.64 emu/g, 56.97 emu/g, 52.43 emu/g, respectively.
Tóm tắt
Nghiên cứu này tổng hợp và đánh giá tính chất hóa lý, từ tính của vật liệu nano Fe3O4@SiO2 có cấu trúc (core–shell) được chức năng hóa với chitosan. Hạt nano Fe3O4 trước tiên được tạo thành bằng phương pháp đồng kết và bao phủ bởi lớp SiO2 bằng cách sử dụng các phân tử silane từ tetraethyl othorsilicate (TEOs) làm tác nhân chuyển pha có ưu điểm tương thích sinh học cao của lớp vỏ silica tạo thành. Hạt nano Fe3O4 sau khi bọc silica được chức năng hóa với chitosan là một polymer có tính tương thích sinh học cao được ứng dụng rộng rãi trong các lĩnh vực y sinh. Kết quả phân tích nhiễu xạ tia X, TEM và từ kế mẫu rung cho thấy hạt nano Fe3O4 có độ kết tinh cao và hạt nano sắt từ thu được có hình khối bát giác với kích thước vào khoảng 20 nm kể cả lớp phủ SiO2. Phân tích hồng ngoại biến đổi Fourier (FT-IR) cho vật liệu Fe3O4@SiO2/CTS thấy được các mũi C-O, N-H, C-H xuất hiện trên phổ minh chứng cho sự tồn tại của chitosan trên bề mặt hạt nano Fe3O4@SiO2 đã chức năng hóa. Kết quả từ kế mẫu rung khẳng định tính siêu thuận từ của vật liệu và độ từ hóa của Fe3O4, Fe3O4@SiO2 và Fe3O4@SiO2/CTS lần lượt là 92,64 emu/g, 56,97 emu/g, 52,43 emu/g.
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