Investigating Flavonoids and biological activities of Curcuma aromatica Salisb extracts
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Abstract
In this study, the raw material is white turmeric (Aromatica Salisb extracts) grown and harvested in the Prong Pak district, Dak Lak province. The material powder is extracted with 4 solvents (ethyl acetate, ethanol, acetone, and petroleum ether) using the soaking method to obtain the corresponding extracts. Then, the extract with the highest flavonoid content was determined for biological activities, including antioxidant, microorganisms, and anti-inflammatory activities. The results of investigating antioxidant activity using the DPPH method showed that white turmeric extract exhibited the ability to resist DPPH free radicals with an IC50 value = 837.06 ± 1.34 µg.mL-1. Results of investigating the antibacterial activity of white turmeric extract using the agar plate diffusion method showed that the extract displayed the ability to inhibit 7 types of pathogenic microorganisms. However, white turmeric extract had weak anti-inflammatory properties.
Tóm tắt
Trong nghiên cứu này, nguyên liệu được sử dụng là củ nghệ trắng (Aromatica Salisb extracts) được trồng và thu hoạch tại huyện Prông Pắk, tỉnh Đắk Lắk. Bột nguyên liệu được chiết flavonoid bằng 4 loại dung môi (ethyl acetate, ethanol, acetone và petroleum ether) bằng phương pháp ngâm để thu được cao chiết tương ứng. Tiếp theo đó, cao chiết có hàm lượng flavonoid cao nhất được xác định hoạt tính sinh học, bao gồm: hoạt tính kháng oxy hóa, kháng vi sinh vật và kháng viêm. Kết quả khảo sát hoạt tính kháng oxy hóa bằng phương pháp DPPH cho thấy cao chiết củ nghệ trắng có khả năng kháng gốc tự do DPPH với giá trị IC50 = 837,06 ± 1,34 µg.mL-1. Kết quả khảo sát hoạt tính kháng vi sinh vật của cao chiết củ nghệ trắng bằng phương pháp khuếch tán qua đĩa thạch cho thấy cao chiết có khả năng ức chế 7 loại vi sinh vật gây bệnh. Tuy nhiên, cao chiết nghệ trắng có tính kháng viêm yếu.
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References
Akaberi, M., Sahebkar, A., & Emami, S. A. (2021). Turmeric and Curcumin: From Traditional to Modern Medicine. Adv Exp Med Biol, 1291,15-39.
https://doi.org/10.1007/978-3-030-56153-6_2. PMID: 34331682.
Baliyan, S., Mukherjee, R., Priyadarshini, A., Vibhuti, A., Gupta, A., Pandey, R. P., & Chang, C. M. (2022). Determination of Antioxidants by DPPH Radical Scavenging Activity and Quantitative Phytochemical Analysis of Ficus religiosa. Molecules, 27, 1326.
https://doi.org/10.3390/ molecules27041326
Bhowmik, D., Chiranjib, Kumar, K. P. S., Chandira, M., & Jayakar, B. (2009). Turmeric: A Herbal and Traditional Medicine. Archives of Applied Science Research, 1(2), 86-108.
Ha, D. T., Phan, M. X. B., Tran, T. B., Nguyen, L. P., Nguyen, N. M., & Vu, T. X. (2022). Evaluation of biological activities of the extracts from Curcuma aromatica Salisb. collected in Yen Bai province. Vietnam Journal of Science and Technology, 64 (10ĐB), 20-23 (in Vietnamese).
https://doi.org/10.31276/VJST.64(10DB).20-23
Ezatia, N., Roberts, M. S., Zhang, Q., & Moghim, H. R. (2020). Measurement of Hansen Solubility Parameters of Human Stratum Corneum. Iranian Journal of Pharmaceutical Research, 19(3), 572-578.
Jyotirmayee, B., & Mahalik, G. (2022). A review on selected pharmacological activities of Curcuma longa L. International Journal of Food Properties, 25(1).
https://doi.org/10.1080/10942912.2022.2082464
Khatun, M., Nur, M.A. Biswas, S., Khan, M., & Amin, M. Z. (2021). Assessment of the anti-oxidant, anti-inflammatory and anti-bacterial activities of different types of turmeric (Curcuma longa) powder in Bangladesh. Journal of Agriculture and Food Research, 6(2021).
https://doi.org/10.1016/j.jafr.2021.100201
Krishnan, S. G., Kokila, M. T., Lakshmi, S. T., &Poovarasan, M. (2024). Exploring the therapeutic potential: A comprehensive review on the Phytochemistry of Curcuma aromatic. World Journal of Biology Pharmacy and Health Sciences, 20(03), 305–312.
https://doi.org/10.30574/wjbphs.2024.20.3.1010
Mba, J. R., Zouheira, D., Dairou, H., Yadang, F. S. A., Gael, N. N., Ayong, L., Kuiate, J. R., & Agbor, G. A. (2022). In Vitro antioxidant, anti-inflammatory, and digestive enzymes inhibition activities of hydro-ethanolic leaf and Bark extracts of Psychotria densinervia (K. Krause) Verdc. Advances in Pharmacological and Pharmaceutical Sciences, 8459943.
https://doi.org/10.1155/2022/8459943.
Nwaekpe, J. O., Anyaegbunam, H. N., Okoye, B. C., & Asumugha, G. N. (2015). Promotion of Turmeric for the Food/Pharmaceutical Industry in Nigeria. American Journal of Experimental Agriculture, 8(6), 335-341.
https://doi.org/10.9734/AJEA/2015/16517
Paiva, L., Rego, C., Lima, E., Marcone, M., & Baptista, J. (2021). Comparative Analysis of the Polyphenols, Caffeine, and Antioxidant Activities of Green Tea, White Tea, and Flowers from Azorean Camellia sinensis Varieties Affected by Different Harvested and Processing Conditions. Antioxidants, 10(183),
https://doi.org/10.3390/antiox10020183.
Prasad, S., & Aggarwal, B. B. (2011). Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine. In Benzie, I.F.F., Wachtel-Galor, S. (Eds.), Herbal Medicine: Biomolecular and Clinical Aspects. Boca Raton (FL) CRC Press/Taylor & Francis.
https://doi.org/10.1201/b10787-14
Ravindran, P. N., Babu, K. N., & Shiva, K. N. (2007). Botany and crop improvement of turmeric. In Ravindran, P. N., Babu, K. N., Shiva, K. N. (Eds.), Turmeric, the Genus Curcuma (15-70). CRC Press/ Taylor & Francis.
https://doi.org/10.1201/9781420006322-8
Rezvanirad, A., Mardani, M., Shirzad, H., Ahmadzadeh, S.M, Asgary, S., Naimi, A., & Mahmoudi, A. (2016). Curcuma longa: A review of therapeutic effects in traditional and modern medical references. Journal of Chemical and Pharmaceutical Sciences, 9(4), 3438-3448.
Sainakham, M., Jantrawut, P., Kiattisin, K., Chittasupho, C., & Singh, S. (2023). Potential of green extraction using edible deep eutectic solvents on the bioactivities from Curcuma aromatica rhizome extracts for food application. Journal of Agriculture and Food Research, 14(2023), 100868.
https://doi.org/10.1016/j.jafr.2023.100868
Thuyen, N. T. B., Thien, Đ. V. H., Hoa, N. V. N., Hang, P. T., & Luan, N. Q. (2025). Study on morphology, biological activities, and chemical compositions of Oenanthe javanica (Blume) DC. essential oil. Chemical paper, 79, 437-445.
https://doi.org/10.1007/s11696-024-03792-w
Dai, T. T. X., Tran, L. C., Nguyen, N. T., Tran,T., Phan, D. K., & Nguyen, T.T. (2018). Investigation of bioactivities of the extract from Premna serratifolia (L.) leaves. CTU Journal of Science, 54(9A), 46-52 (in Vietnamese).
Xia, Q., Zhao, K. J., Huang, Z. G., Zhang, P., Dong, T. T. X., Li, S. P., Tsim, K. W. K. (2005). Molecular genetic and chemical assessment of Rhizoma Curcumae in China. Journal of Agricultural and Food Chemistry, 53(15):, 6019-6026.
http://dx.doi.org/10.1021/jf0508495.
Roy, A., Khan, A., Ahmad, I., Alghamdi, S., Rajab, B. S., Babalghith, A. O., Alshahrani, M. Y., Islam, S., & Islam, M. R. (2022). Flavonoids a Bioactive Compound from Medicinal Plants and Its Therapeutic Applications. Biomed Res Int. 2022 Jun 6;2022:5445291. doi: 10.1155/2022/5445291. PMID: 35707379; PMCID: PMC9192232.
Hao, B., Yang, Z., Liu, H., Liu, Y., & Wang, S. (2024). Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives. Curr. Issues Mol. Biol. 46, 2884-2925. https://doi.org/10.3390/cimb46040181.
Tran, T. V., Tran, H. D., & Vu, L. B. (2024). Vietnamese Medicinal Plants for Cancer Prevention and Treatment. Journal of Science and Technology, Hoa Binh University. 13, 118-123.
Giang, T. C., Pham, L. H. N., & Le, K. T. (2024). Antioxidant and antibacterial activity of fermentation of Curcuma aromatica Salisb. National Scientific Conference on Biotechnology, 439-445.