Investigating synthesis conditions of ZnO microparticles with the supplement of Sonneratia caseolaris L. extract using response surface methodology and evaluating the antioxidant activity of the products
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Abstract
This study focuses on the green synthesis method of ZnO microparticles combined with Sonneratia caseolaris L. leaf extract to find new sources of biologically active materials. Wet-lab experiments were conducted to investigate suitable conditions for green synthesis of these microparticles by adding S. aseolaris leaf extract with the support of Design Expert software using response surface methodology (RSM). The results show suitable conditions for green synthesis of ZnO microparticles: extract concentration of 0.1%, reaction temperature of 50°C, and 1-hour reaction time. The product was investigated for its physicochemical characteristics and antioxidant activity, showing that when the leaf extract was added, the activity of the microparticle system was significantly enhanced, and the difference was statistically significant. This result proposed an essential premise for further research investigating the biological activity and application potential of the green synthesis of ZnO microparticles combined with S. aseolaris leaf extract.
Tóm tắt
Nghiên cứu này tập trung vào phương pháp tổng hợp xanh hệ vi hạt ZnO kết hợp với cao chiết lá Bần chua nhằm tìm ra các nguồn vật liệu mới có hoạt tính sinh học. Các thí nghiệm khảo sát điều kiện thích hợp tổng hợp hệ vi hạt được bố trí thực nghiệm kết hợp với mô hình bề mặt đáp ứng (RSM) và sự hỗ trợ của phần mềm Design Expert. Kết quả cho thấy điều kiện phù hợp để tổng hợp xanh hệ vi hạt ZnO có bổ sung cao chiết là nồng độ cao chiết 0,1%, nhiệt độ phản ứng 50°C và thời gian phản ứng khoảng 1 giờ. Sản phẩm được khảo sát các đặc điểm hóa lý và hoạt tính kháng oxi hóa cho thấy khi có bổ sung cao chiết thì hoạt tính kháng oxi hóa của hệ vi hạt tốt hơn và sự khác biệt có ý nghĩa thống kê. Kết quả này tạo tiền đề quan trọng cho các nghiên cứu tiếp theo về khảo sát hoạt tính sinh học và tiềm năng ứng dụng hệ vi hạt ZnO kết hợp cao chiết lá Bần chua.
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