Exploring the anticancer potential of seven brown algae species against liver and breast cells in Southwest Islands, Vietnam
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Abstract
Cancer is one of the most serious health issues. In the continuous effort to find effective and safe treatment methods, seeking natural sources of anti-cancer agents is an important direction. In this study, the anti-cancer effects of 7 algae species in Southwest Islands, Vietnam, including Padina boryana Thivy, Sargassum sandie, Sargassum glaucescens, Sargassum plagiophyllum, Turbinaria ornata, Caulerpa cupressoides, and Caulerpa taxifolia, were investigated through a series of experiments., targeting both HepG2 (liver cancer) and MCF7 (breast cancer) cells. All extracts from the 7 algae species exhibited cytotoxic effects against both HepG2 and MCF7 cells (cytotoxic effects >50% at 256 µg/mL). Particularly, the C. cupressoides extract demonstrated potent effects against MCF7 and HepG2 cells, with corresponding EC50 values of 50.67 µg/mL and 144.14 µg/mL, respectively.
Tóm tắt
Ung thư là một trong những vấn đề sức khỏe nghiêm trọng. Trong nỗ lực liên tục để tìm ra các phương pháp điều trị hiệu quả và an toàn, việc tìm kiếm các nguồn dược liệu tự nhiên có khả năng chống ung thư là một hướng đi quan trọng. Trong nghiên cứu này, tác dụng chống ung thư của 7 loài tảo ven các đảo vùng Tây Nam Bộ, bao gồm Padina boryana Thivy, Sargassum sandie, Sargassum glaucescens, Sargassum plagiophyllum, Turbinaria ornata, Caulerpa cupressoides, và Caulerpa taxifolia đã được tiến hành thử nghiệm và khảo sát, với đối tượng thử nghiệm là tế bào ung thư gan (HepG2) và ung thư vú (MCF7). Tất cả các dịch chiết từ 7 loài tảo đã cho thấy có tác dụng gây độc đối với tế bào HepG2 và MCF7 (>50% ở nồng độ 256 µg/mL). Đáng chú ý, dịch chiết từ Caulerpa cupressoides có tác dụng mạnh đối với tế bào MCF7 và HepG2, với giá trị EC50 tương ứng là 50,67 µg/mL và 144,14 µg/mL.
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