Tổng hợp dẫn xuất 1,3,4-oxadiazole kết hợp amino acid
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Abstract
This paper reports the design and synthesis of the hybrid 1,3,4-oxadiazole/α-amino acid derivatives from commercially available starting materials under microwave irradiation conditions. Five novel derivatives (6a-e) were successfully synthesized in 9-22% total yields. The structures of the synthesized compounds were fully determined based on spectroscopic data, including HR-MS, FT-IR, 1H-NMR, 13C-NMR, HSQC and HMBC.
Tóm tắt
Bài báo này trình bày kết quả thiết kế và tổng hợp các dẫn xuất 1,3,4-oxadiazole kết hợp α-amino acid từ các tác chất đơn giản trong điều kiện chiếu xạ vi sóng. Năm dẫn xuất mới (6a-e) đã được tổng hợp thành công với hiệu suất toàn phần 9-22%. Cấu trúc các dẫn xuất này được xác định đầy đủ bằng các phương pháp phổ nghiệm bao gồm HR-MS, FT-IR, 1H-NMR, 13C-NMR, HSQC và HMBC.
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