Nghiên cứu các yếu tố ảnh hưởng đến dung dịch phun điện và quá trình phun điện đồng trục đối với vi hạt berberine@chitosan/piperine
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Abstract
In this study, the influence of electrospray solution (including kind of solvent, solvent concentration, and chitosan concentration) and the coaxial electrospray process (including the voltage of needle tip, spray speed, and the distance from the nozzle to the substrate) to the berberine@chitosan/piperine nanoparticles, which were prepared by electrospraying method, were investigated and analyzed. For the electrosprayed solution, two types of solvents were investigated (e.g acetic acid and citric acid), in which acetic acid was chosen to use with the optimum concentration of 90%; the optimum chitosan concentration was 4%. The optimal solution has a conductivity of 745 µS.cm-1, a viscosity of 920 mPa.s, and a surface tension of 30.9 mN.m-1. For the coaxial electrospray process, the optimal sample has a voltage of 17 kV, a spray rate of 0.1/0.2 mL/h, and a distance of 10 cm from the nozzle to the substrate. With the optimal data, the obtained berberine@chitosan/piperine nanoparticles have an almost spherical shape, a core-shell structure, a relatively uniform particle size distribution, and a particle diameter of 203.78 ± 58.56 nm.
Tóm tắt
Trong nghiên cứu này, ảnh hưởng của các yếu tố đến dung dịch phun điện (như loại dung môi, nồng độ dung môi, và nồng độ chitosan) và đến quá trình phun điện đồng trục (như hiệu điện thế đặt vào đầu kim, tốc độ phun, và khoảng cách từ đầu phun đến vị trí thu mẫu) đối với vi hạt berberine@chitosan/piperine được khảo sát và phân tích. Đối với dung dịch phun điện, hai loại dung môi được khảo sát (acetic acid và citric acid), trong đó acetic acid được chọn với nồng độ tối ưu 90%; nồng độ chitosan tối ưu 4%. Dung dịch tối ưu có độ dẫn điện 745 µS.cm-1, độ nhớt 920 mPa.s, sức căng bề mặt 30,9 mN.m-1. Đối với quá trình phun điện đồng trục, mẫu tối ưu có hiệu điện thế 17 kV, tốc độ phun 0,1/0,2 mL/h, và khoảng cách từ đầu phun đến vị trí thu mẫu 10 cm. Với bộ số liệu tối ưu này, các vi hạt berberine@chitosan/piperine thu được có hình dạng gần như hình cầu, có cấu trúc lõi-vỏ, sự phân bố kích thước hạt tương đối đồng đều, đường kính hạt 203,78 ± 58,56 nm.
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